We don't live in a simulation. No one is running the vast numbers of simulations needed to make the hypothesis plausible. The reason is moral. No cyberethics committee, human or not, would sanction creating such simulations and the immense amount of unnecessary suffering they would engender. For any compelling research problem, a more moral approach will be devised. It's the "problem of evil," but magnified by the huge factor that counts how many simulations are running, and have been run, and will be, run. This argument is not telling against the existence of God, but it is compelling against the simulation hypothesis.